MICROTUBULES IN HAMSTER PLATELETS

Microtubules in Hamster Platelets

The increasing frequency with which microtubules are observed in electron micrographs of many cell types has led to much speculation about the possible structural and functional significance of these cytoplasmic elements. Two basic interpretations have been made: that they serve as cytoskeletal elements has been suggested by the work of many investigators (3, 4, 5, 9, 10, 12, 16-18); that they ...

Cytoplasmic microtubules in blood platelets.

Isolation of Circumferential Microtubules From Platelets Without

Circumferential bands of microtubules (MT) support the discoid shape of resting platelets and participate with the contractile apparatus in shape change and internal contraction following activation. Elucidation of interactions between the circumferential coils and proteins of the stable and contractile cytoskeleton is essential for understanding MT function in platelet physiology. A previous i...

Incomplete Microtubules Observed in Mammalian Blood Platelets during Microtubule Polymerization

and 0°C. In both cases the process was reversible (1), 1 the microtubules reappearing when the cold treatment was discontinued. This work deals with the cytoplasmic microtubules in mammalian blood platelets. Unlike the microtubules of the axial filament complex of cilia and flagella, these microtubules are properly preserved only by glutaraldehyde fixation. In platelets the microtubules are arr...

Scrapie infectivity in hamster blood is not associated with platelets.

The infectivity of hamster scrapie strain 263K was measured in platelets isolated from blood pooled from six hamsters with clinical scrapie. The total number of infectious doses present in the blood pool was 220, out of which only 3.5 infectious doses were associated with platelets. A larger proportion of the total infectivity was recovered from the mononuclear leukocyte fraction. This result i...